Electrical potential differences across the foetal membranes of the rabbit.

نویسندگان

  • V KRESPI
  • J DAVIES
چکیده

T H E chemical composition of the foetal fluids in the rabbit was studied by Davies & Routh (1957). These investigators showed that the amniotic and exocoelomic fluids resembled extracellular fluid in their ionic composition whereas the allantoic fluid more closely resembled intracellular fluid. These findings were confirmed by Dickerson & McCance (1957). An experimental study of the trans-membrane potentials in foetal rabbits was undertaken in order to gain some knowledge of their relative permeabilities to certain ions. The process by which a substance is transported across a membrane against its electrochemical gradient is called 'active transport' and requires the expenditure of metabolic energy. If the cell membrane separates ions to which it is differentially permeable, then an electric potential gradient also exists across the membrane. The equilibrium potential for any ion distributed unequally across a membrane may be calculated from the Nernst equation and compared with the actual trans-membrane potential obtained by direct measurement. The membrane is most permeable to the ion whose equilibrium potential best approximates that determined empirically. For example, the Nernst equation for potassium leads to the following expression (25°C):

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عنوان ژورنال:
  • Journal of embryology and experimental morphology

دوره 11  شماره 

صفحات  -

تاریخ انتشار 1963